GSK1324726A ( I-BET726;GSK 1324726A;GSK-1324726A;I-BET 726 )

Catalog No. M11205 CAS No. 1300031-52-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK1324726A
Note

Research use only, not for human use.
Brief Description

A potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively.
Description

A potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively; exhibits growth inhibition with a median growth IC50 value of 75 nM in neuroblastoma cell lines; oral administration to mouse xenograft models of human neuroblastoma results in tumor growth inhibition and down-regulation MYCN and BCL2 expression.
Synonyms

I-BET726;GSK 1324726A;GSK-1324726A;I-BET 726
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

BRD2;BRD3;BRD4
Research Area

Cancer
Indication

——

CAS Number

1300031-52-0
Formula Weight

434.91
Molecular Formula

C25H23ClN2O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 46 mg/mL
SMILES

O=C(O)C1=CC=C(C2=CC3=C(N(C(C)=O)[C@@H](C)C[C@H]3NC4=CC=C(Cl)C=C4)C=C2)C=C1
Chemical Name

Benzoic acid, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]-

1. Gosmini R, et al. J Med Chem. 2014 Oct 9;57(19):8111-31.
2. Wyce A, et al. PLoS One. 2013 Aug 23;8(8):e72967.

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