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Olinone

CAS No. 1770789-37-1

Olinone ( Olinone )

Catalog No. M12666 CAS No. 1770789-37-1

Olinone is a selective inhibitor for the BET BRD1 with Kd of 3.4/3.7/8.6 uM for BRD4-BrD1/BRD3-BrD1/BRD2-BrD1, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Olinone
  • Note
    Research use only, not for human use.
  • Brief Description
    Olinone is a selective inhibitor for the BET BRD1 with Kd of 3.4/3.7/8.6 uM for BRD4-BrD1/BRD3-BrD1/BRD2-BrD1, respectively.
  • Description
    Olinone is a selective inhibitor for the BET BRD1 with Kd of 3.4/3.7/8.6 uM for BRD4-BrD1/BRD3-BrD1/BRD2-BrD1, respectively, shows high selectivity over BET BRD2 (Kd>300 uM); accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation.
  • Synonyms
    Olinone
  • Pathway
    Chromatin/Epigenetic
  • Target
    Bromodomain
  • Recptor
    Bromodomain
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1770789-37-1
  • Formula Weight
    299.37
  • Molecular Formula
    C17H21N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(NCCCCN1C(CCN2)=C(C2=O)C3=C1C=CC=C3)=O
  • Chemical Name
    N-[4-(1-Oxo-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-yl)-butyl]-acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gacias M, et al. Chem Biol. 2014 Jul 17;21(7):841-54.
2. Chiang CM. Chem Biol. 2014 Jul 17;21(7):804-6.
3. Zhao L, et J Neuroinflammation. 2017 Jan 19;14(1):14.al.
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