Cart
sales@molnova.com
XMU-MP-1
CAS No. 2061980-01-4
XMU-MP-1 ( XMU-MP-1; XMU-MP1; XMU-MP 1; XMUMP-1 )
Catalog No. M13204 CAS No. 2061980-01-4
A potent, selective, and ATP-competitive inhibitor of the mammalian Hippo orthologs, Sterile 20–like kinases MST1 and MST2 with IC50 of 71.1 nM and 38.1 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 65 | In Stock |
|
| 5MG | 88 | In Stock |
|
| 10MG | 140 | In Stock |
|
| 25MG | 290 | In Stock |
|
| 50MG | 484 | In Stock |
|
| 100MG | 700 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameXMU-MP-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, and ATP-competitive inhibitor of the mammalian Hippo orthologs, Sterile 20–like kinases MST1 and MST2 with IC50 of 71.1 nM and 38.1 nM, respectively.
-
DescriptionA potent, selective, and ATP-competitive inhibitor of the mammalian Hippo orthologs, Sterile 20–like kinases MST1 and MST2 with IC50 of 71.1 nM and 38.1 nM, respectively; has a selectivity score of 0.05 against a panel of 468 diverse kinases; inhibits phosphorylation of MOB1 in a dose-dependent manner, activates the downstream effector Yes-associated protein (YAP) and promotes cell growth; attenuates acetaminophen-induced liver injury, promotes liver repair and regeneration in mice; a valuable chemical probe to study the Hippo signaling pathway
-
SynonymsXMU-MP-1; XMU-MP1; XMU-MP 1; XMUMP-1
-
PathwayWnt/Notch/Hedgehog
-
TargetHippo
-
RecptorMST1;MST2;MST
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number2061980-01-4
-
Formula Weight416.48
-
Molecular FormulaC17H16N6O3S2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 30 mg/mL
-
SMILESO=S(C1=CC=C(NC2=NC=C3C(N(C)C(C=CS4)=C4C(N3C)=O)=N2)C=C1)(N)=O
-
Chemical NameBenzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Fan F, et al. Sci Transl Med. 2016 Aug 17;8(352):352ra108.
2. Liu Z, et al. Adv Mater. 2017 Oct 11. doi: 10.1002/adma.201703393.
2. Liu Z, et al. Adv Mater. 2017 Oct 11. doi: 10.1002/adma.201703393.
molnova catalog
related products
-
XMU-MP-1
A potent, selective, and ATP-competitive inhibitor of the mammalian Hippo orthologs, Sterile 20–like kinases MST1 and MST2 with IC50 of 71.1 nM and 38.1 nM, respectively.
-
I3MT-3
I3MT-3 (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.
