Cart
sales@molnova.com
WS-3
CAS No. 1421227-52-2
WS-3( WS3 | WS 3 )
Catalog No. M11759 CAS No. 1421227-52-2
A small molecule that can induce proliferation of β cells with EC50 of 74 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 40 | In Stock |
|
| 10MG | 63 | In Stock |
|
| 25MG | 113 | In Stock |
|
| 50MG | 203 | In Stock |
|
| 100MG | 374 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameWS-3
-
NoteResearch use only, not for human use.
-
Brief DescriptionA small molecule that can induce proliferation of β cells with EC50 of 74 nM.
-
DescriptionA small molecule that can induce proliferation of β cells with EC50 of 74 nM; modulates the activity of Erb3 binding protein-1 and the IκB kinase pathway; can reversibly proliferates primary RPE cells isolated from fetal and adult human donors.
-
In VitroWS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC50 value of 0.28 μM.WS3 (1.0 nM-1.0 μM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments.
-
In Vivo——
-
SynonymsWS3 | WS 3
-
PathwayImmunology/Inflammation
-
TargetIκB kinase (IKK)
-
RecptorErbB3-BindingProtein-1(EBP1)|IκBkinase
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number1421227-52-2
-
Formula Weight569.5781
-
Molecular FormulaC28H30F3N7O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 43 mg/mL
-
SMILESCN1CCN(CC2=CC=C(NC(NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1
-
Chemical NameCyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.
molnova catalog
related products
-
AZD3264
A novel IkB-kinase IKK2 inhibitor for treatment of inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.
-
IKK-16 (IKK Inhibito...
IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
-
IKK16
IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.
