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IKK16
CAS No. 1186195-62-9
IKK16( IKK 16 )
Catalog No. M10632 CAS No. 1186195-62-9
IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameIKK16
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NoteResearch use only, not for human use.
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Brief DescriptionIKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.
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DescriptionIKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively; inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM with IC50 of 1.0, 0.5, 0.3 and 0.3 uM respectively; inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis models.
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In Vitro——
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In Vivo——
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SynonymsIKK 16
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorIκB kinase (IKK)
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Research Area——
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Indication——
Chemical Information
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CAS Number1186195-62-9
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Formula Weight535.107
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Molecular FormulaC28H31ClN6OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (192.27 mM)
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SMILESC1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl
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Chemical NameN-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Waelchli R, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12.
2. Thein S, et al. Biochem Biophys Res Commun. 2014 Jul 18;450(1):550-4.
3. Sordi R, et al. Mol Med. 2015 Jun 18;21:563-75.
4. Liu JC, et al. Cell Rep. 2018 Apr 3;23(1):112-126.
molnova catalog
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