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WS-12

CAS No. 68489-09-8

WS-12( —— )

Catalog No. M20758 CAS No. 68489-09-8

WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    WS-12
  • Note
    Research use only, not for human use.
  • Brief Description
    WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM).
  • Description
    WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM).
  • In Vitro
    Acoltremon (10 μM) shows TRPM8 agonism in tests on heterologously expressed TRP ion channels.Acoltremon (1 or 10 μM; 0-250 s) shows highly potent and specific TRPM8 channel agonist in DRG neurons.Cell Viability Assay Cell Line:HEK293T cells Concentration:10 μM Incubation Time:Result:Activated mouse TRPM8 (mTRPM8), but neither activated nor inhibited mTRPA1.Cell Viability Assay Cell Line:Cultured mouse DRG neurons Concentration:1 or 10 μM Incubation Time:0-250 s Result:Showed approximately 10% to 14% of cultured wild-type neurons responsive to WS-12.
  • In Vivo
    Acoltremon (intraperitoneal injection; 10 mg/kg; once) shows analgesic effect by selective TRPM8 activation in mice. Animal Model:Trpm8–/– mice and mice injected with Capsaicin Dosage:10 mg/kg Administration: Intraperitoneal injection; 10 mg/kg; once Result:Produced an obvious analgesic effect, and this effect abolished in Trpm8–/– mice.Showed no change falling latencies in mice in the rotarod test.Reduced Capsaicin-induced nocifensive behavior.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPM8
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    68489-09-8
  • Formula Weight
    289.41
  • Molecular Formula
    C18H27NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:20 mg/mL (69.11 mM)
  • SMILES
    COc1ccc(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1
  • Chemical Name
    (1R2S)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Beck B Bidaux G Bavencoffe A et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators[J]. Cell Calcium 2007 41(3):285-294.
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