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Probenecid
CAS No. 57-66-9
Probenecid( NSC 18786 )
Catalog No. M15105 CAS No. 57-66-9
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 34 | In Stock |
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| 1G | 47 | In Stock |
|
Biological Information
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Product NameProbenecid
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NoteResearch use only, not for human use.
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Brief DescriptionThe prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate.
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DescriptionThe prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
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In Vitro——
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In Vivo——
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SynonymsNSC 18786
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRPV2
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number57-66-9
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Formula Weight285.36
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Molecular FormulaC13H19NO4S
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Purity>98% (HPLC)
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SolubilityEthanol: 22 mg/mL (77.09 mM); DMSO: 57 mg/mL (199.74 mM)
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SMILESCCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
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Chemical Name4-(dipropylsulfamoyl)benzoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Asivatrep
Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons.
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Pyr10
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) (IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells) .
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Capsazepine
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM).?Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel.?It is therefore considered to be a capsaicin antagonist.
