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Home - Products - Wnt/Notch/Hedgehog - Porcupine - WNT-974

WNT-974

CAS No. 1243244-14-5

WNT-974 ( LGK-974;LGK974;LGK 974;WNT 974;WNT974 )

Catalog No. M10986 CAS No. 1243244-14-5

A potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    WNT-974
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay.
  • Description
    A potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay; potently inhibits Wnt signaling with IC50 of 0.4 nM, with no major cytotoxicity; reduces Wnt-dependent LRP6 phosphorylation and the expression of Wnt target genes, such as AXIN2; is potent and efficacious in multiple tumor models at well-tolerated doses in vivo.Colon Cancer Phase 2 Clinical
  • Synonyms
    LGK-974;LGK974;LGK 974;WNT 974;WNT974
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Porcupine
  • Recptor
    Porcn
  • Research Area
    Cancer
  • Indication
    Colon Cancer

Chemical Information

  • CAS Number
    1243244-14-5
  • Formula Weight
    396.44
  • Molecular Formula
    C23H20N6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 32 mg/mL
  • SMILES
    O=C(NC1=NC=C(C2=NC=CN=C2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=C3
  • Chemical Name
    [2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu J, et al. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9.
2. Jiang X, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54.
3. Moon J, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654.
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