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WM-3835
CAS No. 2229025-70-9
WM-3835( —— )
Catalog No. M24012 CAS No. 2229025-70-9
WM-3835 is a novel and high-specific small molecule?inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1)?, able to potently suppressed OS cell proliferation and migration, and leads to?apoptosis?activation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 215 | In Stock |
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| 50MG | 340 | In Stock |
|
| 100MG | 533 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameWM-3835
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NoteResearch use only, not for human use.
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Brief DescriptionWM-3835 is a novel and high-specific small molecule?inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1)?, able to potently suppressed OS cell proliferation and migration, and leads to?apoptosis?activation.
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DescriptionWM-3835 is a novel and high-specific small molecule?inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1)?, able to potently suppressed OS cell proliferation and migration, and leads to?apoptosis?activation.
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In VitroWM-3835 (1-25 uM; 24-96 hours) inhibits pOS-1 cell viability in a concentration-dependent manner. WM-3835 (5 uM; 72 h) activates cell apoptosis and significantly increases TUNEL-positive nuclei in pOS-1 cells. WM-3835 (5 μM; 24 hours) downregulates MYLK-HOXA9 mRNA expression in pOS-1 cells. WM-3835 (1-25 uM) suppresses H4K12ac-H3K14ac in a dose-dependent manner. WM-3835 does not alter the expressions of HBO1 protein and total H3, H4 histones. WM-3835 (5 μM) fails to induce apoptosis and reduction of viability in HBO1-KO pOS-1 cells, koHBO1-1 and koHBO1-2, HBO1-low human osteoblasts. Cell Viability Assay Cell Line:Primary human OS (pOS-1) cells Concentration:1, 5, 10, 25 uM Incubation Time:24, 48, 72, 96 hours Result:Inhibited pOS-1 cell viability in a concentration-dependent manner. Exerted a significant anti-survival activity at least 48 h, displaying a time-dependent manner.Apoptosis Analysis Cell Line:pOS-1 cells Concentration:5 uM Incubation Time:72 hours Result:Activated cell apoptosis and significantly increases TUNEL-positive nuclei.RT-PCR Cell Line:pOS-1 cells Concentration:5 uM Incubation Time:24 hours Result:Downregulated MYLK-HOXA9 mRNA expression.
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In VivoWM-3835 (10 mg/kg/day; ip; for21 days) potently inhibits pOS-1 xenograft growth in SCID mice. Animal Model:SCID mice (18-19 g, female) with pOS1 cells Dosage:10 mg/kg Administration:IP; daily; for 21 daysResult:Potently inhibited pOS-1 xenograft growth.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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Recptorapoptosis|Lysine Acetyltransferase 7
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Research Area——
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Indication——
Chemical Information
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CAS Number2229025-70-9
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Formula Weight400
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Molecular FormulaC20H17FN2O4S
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (624.34 mM; Need ultrasonic)
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SMILESCC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC(O)=CC=C3)=O)=O)=C1F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yan-Yang Gao, et al. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Theranostics. 2021 Mar 4;11(10):4599-4615.
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