Cart
sales@molnova.com
ZDLD20
CAS No. 2762279-02-5
ZDLD20( —— )
Catalog No. M35585 CAS No. 2762279-02-5
ZDLD20 is an orally active and selective CDK4 inhibitor, a β-carboline analog with anti-HCT116 and anticancer activity that inhibits colony formation, inhibits invasion and migration, induces apoptosis, and prevents the G1 phase of the cell cycle.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 73 | Get Quote |
|
| 5MG | 107 | Get Quote |
|
| 10MG | 176 | Get Quote |
|
| 25MG | 342 | Get Quote |
|
| 50MG | 548 | Get Quote |
|
| 100MG | 858 | Get Quote |
|
| 500MG | 1692 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameZDLD20
-
NoteResearch use only, not for human use.
-
Brief DescriptionZDLD20 is an orally active and selective CDK4 inhibitor, a β-carboline analog with anti-HCT116 and anticancer activity that inhibits colony formation, inhibits invasion and migration, induces apoptosis, and prevents the G1 phase of the cell cycle.
-
DescriptionZDLD20, a β-carboline, is orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 6.51 μM. ZDLD20 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD20 exhibits potent anticancer activity.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2762279-02-5
-
Formula Weight386.45
-
Molecular FormulaC22H22N6O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(NC1=NC=C(C=C1)N2CCN(C)CC2)C3=NC=CC=4C=5C=CC=CC5NC34
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Deping Li, et al. Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer. Bioorg Chem. 2022 Apr;121:105659.?
molnova catalog
related products
-
Hydroxy-PP-Me
Hydroxy-PP-Me is a potent and specific CBR1 inhibitor with an IC50 of 759 nM. It inhibits serum-withdrawal-induced apoptosis and, when used in conjunction with As2O3, enhances As2O3-induced apoptotic cell death .
-
Myristoleic acid
Myristoleic acid is a cytotoxic component in the extract from Serenoa repens. Myristoleic acid induces apoptosis and necrosis in human prostatic LNCaP cells.
-
SACLAC
SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity that decreases AML cell viability, inhibits AML cell proliferation, increases AML cell death, and induces apoptosis of AML cells, and is used in the study of acute myeloid leukemia and cancer.
