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WIKI4
CAS No. 838818-26-1
WIKI4( WIKI-4 )
Catalog No. M16111 CAS No. 838818-26-1
A novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 51 | In Stock |
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| 10MG | 76 | In Stock |
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| 25MG | 145 | In Stock |
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| 50MG | 268 | In Stock |
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| 100MG | 444 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameWIKI4
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NoteResearch use only, not for human use.
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Brief DescriptionA novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2.
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DescriptionA novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2; prevents auto-ADP-ribosylation of TNKS2 with IC50 of 15 nM; inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in cancer cell lines as well as in human embryonic stem cells.
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In VitroCell Viability Assay Cell Line:DLD1 cells Concentration:100 nM, 1 μM Incubation Time:6 days Result:Inhibited growth of DLD1 cells. Western Blot Analysis Cell Line:DLD1 cells Concentration:1 μM Incubation Time:2 hours,4 hours,6 hours, or 24 hours Result:Significantly increased the steady-state abundance of AXIN1 and AXIN2.
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In Vivo——
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SynonymsWIKI-4
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PathwayWnt/Notch/Hedgehog
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TargetBeta-catenin
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RecptorTNKS2
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number838818-26-1
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Formula Weight521.5896
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Molecular FormulaC29H23N5O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 6.8 mg/mL
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SMILESO=C(NC1=CC=CC=C1C(NC2=CC=C(CCN3CC4=C(C=C(OC)C(OC)=C4)CC3)C=C2)=O)C5=CC=C(OC)C(OC)=C5
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Chemical Name1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[3-[[4-(4-methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. James RG, et al. PLoS One. 2012;7(12):e50457.
2. Haikarainen T, et al. PLoS One. 2013 Jun 6;8(6):e65404.
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