Cart
sales@molnova.com
Home - Products - Wnt/Notch/Hedgehog - Beta-catenin - PNU-74654

PNU-74654

CAS No. 113906-27-7

PNU-74654( PNU74654 | PNU 74654 )

Catalog No. M10489 CAS No. 113906-27-7

A novel potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction; binds to β-catenin with Kd of 450 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 46 In Stock
10MG 65 In Stock
25MG 138 In Stock
50MG 257 In Stock
100MG 464 In Stock
200MG 672 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PNU-74654
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction; binds to β-catenin with Kd of 450 nM.
  • Description
    A novel potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction; binds to β-catenin with Kd of 450 nM, significantly decreases NCI-H295 cell proliferation (96 h, IC50=69 nM), increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impaires CTNNB1/beta-catenin expression and increases beta-catenin target genes.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PNU74654 | PNU 74654
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Beta-catenin
  • Recptor
    Beta-catenin
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    113906-27-7
  • Formula Weight
    320.34194
  • Molecular Formula
    C19H16N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    O=C(N/N=C/C1=CC=C(C)O1)C2=CC=CC=C2OC3=CC=CC=C3
  • Chemical Name
    Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Leal LF, et al. Oncotarget. 2015 Dec 15;6(40):43016-32. 2. Trosset JY, et al. Proteins. 2006 Jul 1;64(1):60-7. 3. Wang H, et al. Inflamm Res. 2016 Jan;65(1):61-9.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • R-360163

    R-360163 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 16 uM in FP assay.

  • ZTM000990

    ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.

  • Triptonide

    A key bioactive small molecule identified in Tripterygium wilfordii Hook F., has a broad spectrum of biological functions.

Sign In Join Free