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WF-210
CAS No. 1242279-00-0
WF-210( WF210 )
Catalog No. M10980 CAS No. 1242279-00-0
WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1053 | Get Quote |
|
| 50MG | 2142 | Get Quote |
|
| 100MG | 2790 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameWF-210
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NoteResearch use only, not for human use.
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Brief DescriptionWF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM.
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DescriptionWF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM, displays more cytotoxic than PAC‐1 to human cancer cells, but less cytotoxic to normal cells; exhibits an enhanced zinc chelating ability (EC50=2.88 uM) compared to PAC‐1, activates procaspase-3 through relief of zinc-mediated inhibition; more potently induces cancer cell death in vitro with mean IC50 of 0.88 uM against 15 cancer cell lines, induces apoptosis in HL-60 and U-937 cells via a caspase-dependent pathway, activates procaspase-3, reduces IAPs, and inhibits tumor growth in breast, liver, and gallbladder xenograft tumor models.
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In Vitro——
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In Vivo——
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SynonymsWF210
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase
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Research Area——
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Indication——
Chemical Information
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CAS Number1242279-00-0
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Formula Weight791.855
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Molecular FormulaC41H38FN7O7S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N/N=C/C1=CC=C(OCC2=CSC(CC3=CC=C(OCO4)C4=C3)=N2)C=C1O)CN5CCN(CC6=NC(C7=CC=C(COC8=CC=C(F)C=C8)C=C7)=NO6)CC5
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Chemical NameN'-(4-((2-(benzo[d][1,3]dioxol-5-ylmethyl)thiazol-4-yl)methoxy)-2-hydroxybenzylidene)-2-(4-((3-(4-((4-fluorophenoxy)methyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)piperazin-1-yl)acetohydrazide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang F, et al. Eur J Pharmacol. 2018 Feb 15;821:29-38.
2. Wang F, et al. Mol Oncol. 2014 Dec;8(8):1640-52.
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