IDN-7314( IDN7314 | IDN 7314 )

Catalog No. M13762 CAS No. 254750-11-3

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Product Name

IDN-7314
Note

Research use only, not for human use.
Brief Description

A potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8.
Description

A potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8; also potently inhibited Fas-induced apoptosis of Jurkat cells with IC50 of 6.3 nM, demonstrates protective activity in the mouse model of Fas-induced hepatitis (ED50=0.7mg/kg, p.o.); synergistically inhibits tumor growth by activation of necroptosis and increased secretion of TNFα in a model of colon carcinoma combined with 5-FU.
In Vitro

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In Vivo

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Synonyms

IDN7314 | IDN 7314
Pathway

Apoptosis
Target

Caspase
Recptor

Caspase
Research Area

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Indication

——

CAS Number

254750-11-3
Formula Weight

549.382
Molecular Formula

C22H17F6N3O7
Purity

>98% (HPLC)
Solubility

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SMILES

CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=C(C=CC=C2F)F
Chemical Name

(S)-3-((S)-2-(2-((2,6-difluorophenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

1. Oliver Metzig M, et al. Oncogene. 2016 Jun 30;35(26):3399-409. 2. Ueno H, et al. Bioorg Med Chem Lett. 2009 Jan 1;19(1):199-202.

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