WEHI-345 ( WEHI-345; WEHI345; WEHI 345 )

Catalog No. M11450 CAS No. 1354825-58-3

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Datasheet

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Product Name

WEHI-345
Note

Research use only, not for human use.
Brief Description

A potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM; displays negligible activity (>10 uM) against RIPK1, RIPK4 and RIPK5.
Description

A potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM; displays negligible activity (>10 uM) against RIPK1, RIPK4 and RIPK5; delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement; prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice.
Synonyms

WEHI-345; WEHI345; WEHI 345
Pathway

Apoptosis
Target

RIP kinase
Recptor

RIPK2
Research Area

Cancer
Indication

——

CAS Number

1354825-58-3
Formula Weight

401.46
Molecular Formula

C22H23N7O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 32 mg/mL
SMILES

O=C(NCC(C)(N1N=C(C2=CC=C(C)C=C2)C3=C(N)N=CN=C31)C)C4=CC=NC=C4
Chemical Name

4-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-

1. Nachbur U, et al. Nat Commun. 2015 Mar 17;6:6442.

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