Cart
sales@molnova.com
Volasertib
CAS No. 755038-65-4
Volasertib ( BI 6727;BI-6727;BI6727 )
Catalog No. M15871 CAS No. 755038-65-4
Volasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 50 | In Stock |
|
| 5MG | 84 | In Stock |
|
| 10MG | 149 | In Stock |
|
| 25MG | 261 | In Stock |
|
| 50MG | 471 | In Stock |
|
| 100MG | 683 | In Stock |
|
| 500MG | 1422 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameVolasertib
-
NoteResearch use only, not for human use.
-
Brief DescriptionVolasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively.
-
DescriptionVolasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively; displays no inhibitory activity against a panel of >50 other kinases; inhibits proliferation of multiple cell lines derived from various cancer tissues, including HCT116 (EC50=23 nM) and NCI-H460 (EC50=21 nM),BRO (EC50=11 nM), and hematopoietic cancer cell HL-60 (EC50=32 nM); demonstrates marked antitumor activity in multiple cancer models, including a model of taxane-resistant colorectal cancer.Blood Cancer Phase 3 Clinical
-
SynonymsBI 6727;BI-6727;BI6727
-
PathwayCell Cycle/DNA Damage
-
TargetPLK
-
RecptorPLK1
-
Research AreaCancer
-
IndicationBlood cancer
Chemical Information
-
CAS Number755038-65-4
-
Formula Weight618.81
-
Molecular FormulaC34H50N8O3
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(N[C@H]1CC[C@@H](N2CCN(CC3CC3)CC2)CC1)C4=CC=C(NC(N=C5N(C(C)C)[C@@H]6CC)=NC=C5N(C)C6=O)C(OC)=C4
-
Chemical NameBenzamide, N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Rudolph D, et al. Clin Cancer Res. 2009 May 1;15(9):3094-102.
2. Grinshtein N, et al. Cancer Res. 2011 Feb 15;71(4):1385-95.
3. Schffski P, et al. Eur J Cancer. 2012 Jan;48(2):179-86.
4. Sanhaji M, et al. Cell Cycle. 2012 Feb 1;11(3):543-53.
2. Grinshtein N, et al. Cancer Res. 2011 Feb 15;71(4):1385-95.
3. Schffski P, et al. Eur J Cancer. 2012 Jan;48(2):179-86.
4. Sanhaji M, et al. Cell Cycle. 2012 Feb 1;11(3):543-53.
molnova catalog
related products
-
Volasertib
Volasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively.
-
Pyridoxine
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body.
-
CFI-400945
CFI-400945 is an potent, selective and orally active inhibitor of?polo-like kinase 4(PLK4; Ki value of 0.26 nM).
