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BI-2536
CAS No. 755038-02-9
BI-2536 ( BI 2536;BI2536 )
Catalog No. M15870 CAS No. 755038-02-9
A potent and selective inhibitor of PLK1 with IC50 of 0.83 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
|
| 5MG | 80 | In Stock |
|
| 25MG | 113 | In Stock |
|
| 50MG | 186 | In Stock |
|
| 100MG | 332 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBI-2536
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of PLK1 with IC50 of 0.83 nM.
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DescriptionA potent and selective inhibitor of PLK1 with IC50 of 0.83 nM; also weakly inhibits the activities of PLK2 and PLK3 (IC50=3.5 nM and 9.0 nM, respectively), displays >1,000-fold selectivity to a panel of 63 other protein kinases; causes a mitotic arrest and induces apoptosis in human cancer cell lines, inhibits growth of human tumor xenografts in nude mice and induces regression of large tumors with well-tolerated intravenous dose regimens; also inhibits BRD4 with IC50 of 25 nM.Blood Cancer Phase 2 Clinical
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SynonymsBI 2536;BI2536
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PathwayCell Cycle/DNA Damage
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TargetPLK
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RecptorMet;PI3Kα;PLK1;PLK2;PLK3
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number755038-02-9
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Formula Weight521.65
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Molecular FormulaC28H39N7O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1CCN(C)CC1)C2=CC=C(NC(N=C3N(C4CCCC4)[C@@H]5CC)=NC=C3N(C)C5=O)C(OC)=C2
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Chemical NameBenzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Steegmaier M, et al. Curr Biol. 2007 Feb 20;17(4):316-22. Epub 2007 Feb 8.
2. Chen L, et al. ACS Med Chem Lett. 2015 May 18;6(7):764-9.
3. Nappi TC, et al. Cancer Res. 2009 Mar 1;69(5):1916-23.
2. Chen L, et al. ACS Med Chem Lett. 2015 May 18;6(7):764-9.
3. Nappi TC, et al. Cancer Res. 2009 Mar 1;69(5):1916-23.
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