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Velusetrag

CAS No. 866933-46-2

Velusetrag ( TD-5108 )

Catalog No. M16300 CAS No. 866933-46-2

Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Velusetrag
  • Note
    Research use only, not for human use.
  • Brief Description
    Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7.
  • Description
    Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7, shows >500-fold selectivity over other 5-HT receptors; displays >25-fold selectivity over other biogenic amine receptors, and no effect on hERG channels; increases the contractility of the canine antrum, duodenum and jejunum with higher potency than tegaserod, demonstrates robust in vivo activity in the guinea pig, rat and dog gastrointestinal tracts.Other Indication Phase 2 Clinical
  • Synonyms
    TD-5108
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    866933-46-2
  • Formula Weight
    504.65
  • Molecular Formula
    C25H36N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC2=C(N(C(C)C)C1=O)C=CC=C2)NC3CC(N4C[C@@H](O)CN(C)S(=O)(C)=O)([H])CCC4([H])C3
  • Chemical Name
    N-((1R,3R,5S)-8-((R)-2-hydroxy-3-(N-methylmethylsulfonamido)propyl)-8-azabicyclo[3.2.1]octan-3-yl)-1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Beattie DT, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):139-47.
2. Smith JA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37.
3. Manini ML, et al. Neurogastroenterol Motil. 2010 Jan;22(1):42-9, e7-8.
4. Long DD, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6048-52.
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