Velusetrag
CAS No. 866933-46-2
Velusetrag ( TD-5108 )
Catalog No. M16300 CAS No. 866933-46-2
Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 262 | Get Quote |
|
50MG | 1341 | Get Quote |
|
100MG | 2025 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVelusetrag
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NoteResearch use only, not for human use.
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Brief DescriptionVelusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7.
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DescriptionVelusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7, shows >500-fold selectivity over other 5-HT receptors; displays >25-fold selectivity over other biogenic amine receptors, and no effect on hERG channels; increases the contractility of the canine antrum, duodenum and jejunum with higher potency than tegaserod, demonstrates robust in vivo activity in the guinea pig, rat and dog gastrointestinal tracts.Other Indication Phase 2 Clinical
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SynonymsTD-5108
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number866933-46-2
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Formula Weight504.65
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Molecular FormulaC25H36N4O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=CC2=C(N(C(C)C)C1=O)C=CC=C2)NC3CC(N4C[C@@H](O)CN(C)S(=O)(C)=O)([H])CCC4([H])C3
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Chemical NameN-((1R,3R,5S)-8-((R)-2-hydroxy-3-(N-methylmethylsulfonamido)propyl)-8-azabicyclo[3.2.1]octan-3-yl)-1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beattie DT, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):139-47.
2. Smith JA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37.
3. Manini ML, et al. Neurogastroenterol Motil. 2010 Jan;22(1):42-9, e7-8.
4. Long DD, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6048-52.
2. Smith JA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37.
3. Manini ML, et al. Neurogastroenterol Motil. 2010 Jan;22(1):42-9, e7-8.
4. Long DD, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6048-52.
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