
Vacuolin-1
CAS No. 351986-85-1
Vacuolin-1( Vacuolin 1 | Vacuolin1 )
Catalog No. M14199 CAS No. 351986-85-1
A potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 65 | In Stock |
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10MG | 102 | In Stock |
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25MG | 196 | In Stock |
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50MG | 356 | In Stock |
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100MG | 530 | In Stock |
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500MG | 1152 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameVacuolin-1
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NoteResearch use only, not for human use.
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Brief DescriptionA potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.
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DescriptionA potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A; blocks the Ca(2+)-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding, without affecting the process of resealing, induces the formation of giant vacuoles.
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In VitroVacuolin-1 (1 μM; Pretreatment 1 hour) blocks ionomycin-induced exocytosis of lysosomes but not of enlargeosomes. It results in vacuolation of lysosomes (A) and complete inhibition of the surface expression of Lamp-1. Vacuolin-1 (1 μM; 20-180 min) disrupts the segregation of inner and limiting membranes characteristic of endosomes and lysosomes. Ultrastructural analysis also shows that vacuolin-1 favours fusion of inner and limiting membranes.Vacuolin-1 (5 or 10 μM; 2 hours) blocks the Ca2+-dependent release of β-hexosaminidase from lysosomes. In HeLa cells, ionomycin results in the expected release of 18-20% of lysosomal β-hexosaminidase. But when cells pretreated with vacuolin-1, releases no more β-hexosaminidase compared with cells that are not exposed to ionomycin (4%).
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In Vivo——
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SynonymsVacuolin 1 | Vacuolin1
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number351986-85-1
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Formula Weight577.4
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Molecular FormulaC26H24IN7O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (17.32 mM)
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SMILESIC1=CC(/C=N/NC2=NC(N(C3=CC=CC=C3)C4=CC=CC=C4)=NC(N5CCOCC5)=N2)=CC=C1
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Chemical Name(E)-4-(2-(3-iodobenzylidene)hydrazinyl)-6-morpholino-N,N-diphenyl-1,3,5-triazin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cerny J, et al. EMBO Rep. 2004 Sep;5(9):883-8.
2. Shaik GM, et al. Cell Signal. 2009 Aug;21(8):1337-45.
3. Lu Y, et al. Autophagy. 2014;10(11):1895-905.
4. Sano O, et al. FEBS Lett. 2016 Jun;590(11):1576-85.
molnova catalog



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