Hemin ( Hemin chloride )

Catalog No. M12298 CAS No. 16009-13-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Hemin
Note

Research use only, not for human use.
Brief Description

Hemin, a physiological erythroid maturation stimulator, is able to induce the expression of critical autophagic genes (Map1a1b (LC3), Beclin-1 gen, Atg5) in an erythroleukemia cell type.
Description

Hemin, a physiological erythroid maturation stimulator, is able to induce the expression of critical autophagic genes (Map1a1b (LC3), Beclin-1 gen, Atg5) in an erythroleukemia cell type; increases the size of autophagic vacuoles and induces mitophagy in K562 cells; a heme oxygenase (HO)1 inducer.
Synonyms

Hemin chloride
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

Cardiovascular Disease
Indication

——

CAS Number

16009-13-5
Formula Weight

651.94
Molecular Formula

C34H32ClFeN4O4
Purity

>98% (HPLC)
Solubility

DMSO: 6.6 mg/mL
SMILES

CC1=C(CCC(O)=O)/C2=C/C3=C(CCC(O)=O)C(C)=C(/C=C4C(C)=C(C=C)C(/C=C5C(C)=C(C=C)C(/C=C1\[N-]2)=N/5)=N/4)[N-]3.[Fe+3]
Chemical Name

Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-5-13)-

1. Fader CM, et al. Biol Cell. 2016 Apr;108(4):77-95.
2. Higdon AN, et al. Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1394-409.

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