VUF10460

CAS No. 1028327-66-3

VUF10460( —— )

Catalog No. M17121 CAS No. 1028327-66-3

VUF10460 is a non-imidazole histamine H4 receptor agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 29 In Stock
5MG 47 In Stock
10MG 77 In Stock
25MG 149 In Stock
50MG 259 In Stock
100MG 405 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    VUF10460
  • Note
    Research use only, not for human use.
  • Brief Description
    VUF10460 is a non-imidazole histamine H4 receptor agonist.
  • Description
    VUF10460 is a non-imidazole histamine H4 receptor agonist.
  • In Vitro
    UF10460 binds to rat H3 and H4 receptor with pKi values of 5.75, and 7.46, respectively. VUF10460 displays approximately a 50-fold selectivity for the rat H4 receptor over the H3 receptor.
  • In Vivo
    HCl-induced rat gastric lesions is significantly enhanced by the H4 receptor agonists VUF10460. This effect is not modified by H4 receptor antagonist JNJ7777120.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    H4 receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1028327-66-3
  • Formula Weight
    269.35
  • Molecular Formula
    C15H19N5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 36 mg/mL 133.66 mM
  • SMILES
    CN1CCN(CC1)c1cc(c2ccccc2)nc(N)n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Coruzzi G, et al. Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur J Pharmacol. 2011 Nov 1;669(1-3):121-7.
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