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Home - Products - MAPK/ERK Signaling - Raf - Uplarafenib

Uplarafenib

CAS No. 1425485-87-5

Uplarafenib( —— )

Catalog No. M35714 CAS No. 1425485-87-5

Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 of 50-100 nM. B-Raf IN 10 exhibits antitumor activity that may influence cell proliferation and differentiation, making it suitable for studying solid tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Uplarafenib
  • Note
    Research use only, not for human use.
  • Brief Description
    Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 of 50-100 nM. B-Raf IN 10 exhibits antitumor activity that may influence cell proliferation and differentiation, making it suitable for studying solid tumors.
  • Description
    Uplarafenib (B-Raf IN 10) (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. Uplarafenib shows antitumor activity.
  • In Vitro
    Uplarafenib (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E.Uplarafenib shows an IC50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E.Uplarafenib (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells.Cell Viability Assay Cell Line:A375, SK-MEL-28, SK-MEL-31 and CHL-1 Concentration:Incubation Time:72 h Result:Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Raf
  • Recptor
    Raf
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1425485-87-5
  • Formula Weight
    494.49
  • Molecular Formula
    C22H21F3N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (202.23 mM; Ultrasonic (<60°C)
  • SMILES
    CCCS(=O)(=O)Nc1cc(F)c(F)c(C(=O)c2ccc3ncc(nc3c2)N2CCOCC2)c1F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yong-Liang Zhu, et al. Certain Chemical Entities, Compositions, and Methods. Patent US20130053384 A1.
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