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AZ 628
CAS No. 878739-06-1
AZ 628( AZ-628 | AZ628 )
Catalog No. M16378 CAS No. 878739-06-1
AZ 628(AZ-628, AZ628) is a potent and selective B-Raf inhibitor with IC50s of 2.14 uM and 0.19 uM for wt Braf and Braf V600E respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | Get Quote |
|
| 5MG | 55 | Get Quote |
|
| 10MG | 84 | Get Quote |
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| 25MG | 164 | Get Quote |
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| 50MG | 259 | Get Quote |
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| 100MG | 336 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAZ 628
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NoteResearch use only, not for human use.
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Brief DescriptionAZ 628(AZ-628, AZ628) is a potent and selective B-Raf inhibitor with IC50s of 2.14 uM and 0.19 uM for wt Braf and Braf V600E respectively.
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DescriptionAZ 628(AZ-628, AZ628) is a potent and selective B-Raf inhibitor with IC50s of 2.14 uM and 0.19 uM for wt Braf and Braf V600E respectively.
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In VitroAZ 628 reduces activities of preactivated B-Raf, B-RafV600E, and c-Raf-1 in in vitro kinase assays, with IC50 values of 105, 34 and 29 nM, respectively. AZ 628 also inhibits activation of number of tyrosine protein kinases including VEGFR2, DDR2, Lyn, Flt1, FMS and others. AZ 628 inhibits anchorage-dependent and -independent growth, causes cell cycle arrest, and induces apoptosis in colon and melanoma cell lines harboring B-RafV600E mutation. AZ 628 suppresses growth in cells expressing K-RASG13D. Inhibition of RAF with AZ 628 suppresses MEK and ERK phosphorylation. AZ 628 selectively affects viability in K-RAS mutant cells.
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In Vivo——
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SynonymsAZ-628 | AZ628
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PathwayMAPK/ERK Signaling
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TargetRaf
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RecptorB-Raf| B-Raf (V600E)| C-Raf-1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number878739-06-1
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Formula Weight451.5197
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Molecular FormulaC27H25N5O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=C(C)C(NC2=CC3=C(N=CN(C)C3=O)C=C2)=C1)C4=CC=CC(C(C)(C#N)C)=C4
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Chemical NameBenzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McDermott U, et al. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41.
2. Wenglowsky S, et al. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1923-7.
3. Whittaker SR, et al. Cancer Discov. 2013 Mar;3(3):350-62.
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