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Home - Products - Proteasome/Ubiquitin - DUB - USP8-IN-22e

USP8-IN-22e

CAS No. 924296-19-5

USP8-IN-22e( —— )

Catalog No. M16623 CAS No. 924296-19-5

A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    USP8-IN-22e
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM.
  • Description
    A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM; shows no inhibitory activity for USP7 (IC50>100 uM).
  • In Vitro
    DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    924296-19-5
  • Formula Weight
    275.2649
  • Molecular Formula
    C15H9N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 9.06 mg/mL
  • SMILES
    CCON=C1C2=CC=CC=C2C3=NC(=C(N=C31)C#N)C#N
  • Chemical Name
    9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-(ethoxyimino)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Colombo M, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.
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