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IU-1
CAS No. 314245-33-5
IU-1 ( USP14 inhibitor IU1 )
Catalog No. M14014 CAS No. 314245-33-5
IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 49 | In Stock |
|
| 10MG | 68 | In Stock |
|
| 25MG | 131 | In Stock |
|
| 50MG | 227 | In Stock |
|
| 100MG | 403 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIU-1
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NoteResearch use only, not for human use.
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Brief DescriptionIU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.
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DescriptionIU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM; displays no activity against other human eight DUBs (Uch37, Uch-L1/L3, USP7, etc.); enhances proteasomal degradation in vivo, attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; also inhibits Dengue virus replication.
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SynonymsUSP14 inhibitor IU1
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorUSP14
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number314245-33-5
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Formula Weight300.38
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Molecular FormulaC18H21FN2O
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Purity>98% (HPLC)
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SolubilityDMSO: 30 mg/mL (100 mM); Ethanol: 15 mg/mL (50 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESCC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3
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Chemical Name1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee BH, et al. Nature. 2010 Sep 9;467(7312):179-84.
2. Nag DK, et al. Virus Res. 2012 Apr;165(1):103-6.
3. Lahaie N, et al. J Biol Chem. 2016 Mar 25;291(13):7156-70.
4. Min JW, et al. J Neurochem. 2017 Mar;140(5):826-833.
2. Nag DK, et al. Virus Res. 2012 Apr;165(1):103-6.
3. Lahaie N, et al. J Biol Chem. 2016 Mar 25;291(13):7156-70.
4. Min JW, et al. J Neurochem. 2017 Mar;140(5):826-833.
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