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IU-1

CAS No. 314245-33-5

IU-1 ( USP14 inhibitor IU1 )

Catalog No. M14014 CAS No. 314245-33-5

IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IU-1
  • Note
    Research use only, not for human use.
  • Brief Description
    IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.
  • Description
    IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM; displays no activity against other human eight DUBs (Uch37, Uch-L1/L3, USP7, etc.); enhances proteasomal degradation in vivo, attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; also inhibits Dengue virus replication.
  • Synonyms
    USP14 inhibitor IU1
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    USP14
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    314245-33-5
  • Formula Weight
    300.38
  • Molecular Formula
    C18H21FN2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 30 mg/mL (100 mM); Ethanol: 15 mg/mL (50 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3
  • Chemical Name
    1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lee BH, et al. Nature. 2010 Sep 9;467(7312):179-84.
2. Nag DK, et al. Virus Res. 2012 Apr;165(1):103-6.
3. Lahaie N, et al. J Biol Chem. 2016 Mar 25;291(13):7156-70.
4. Min JW, et al. J Neurochem. 2017 Mar;140(5):826-833.
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