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USP7i-1
CAS No. 1381291-36-6
USP7i-1( USP7 inhibitor 1 )
Catalog No. M11579 CAS No. 1381291-36-6
USP7i-1 is a potent, selective USP7 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 210 | Get Quote |
|
| 5MG | 312 | Get Quote |
|
| 10MG | 447 | Get Quote |
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| 25MG | 714 | Get Quote |
|
| 50MG | 1017 | Get Quote |
|
| 100MG | 1368 | Get Quote |
|
| 500MG | 2673 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameUSP7i-1
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NoteResearch use only, not for human use.
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Brief DescriptionUSP7i-1 is a potent, selective USP7 inhibitor.
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DescriptionUSP7i-1 is a potent, selective USP7 inhibitor.
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In VitroUSP7-IN-1 (Example 2) is a selective and reversible inhibitor of USP7, with an IC50 of 77 μM, and shows no inhibition of USP8, USP5, Uch-L1, Uch-L3 or caspase 3. USP7-IN-1 inhibits the proliferation of HCT116 cells, with a GI50 of 67 μM.
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In Vivo——
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SynonymsUSP7 inhibitor 1
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1381291-36-6
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Formula Weight425.913
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Molecular FormulaC23H24ClN3O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 40 mg/mL 93.92 mM
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SMILESC1CN(CCC1(CN2C=NC3=C(C2=O)C=CC(=C3)Cl)O)C(=O)CCC4=CC=CC=C4
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Chemical Name7-chloro-3-((4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl)methyl)quinazolin-4(3H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Weisberg EL, et al. Nat Chem Biol. 2017 Dec;13(12):1207-1215.
2. Kessler BM. Expert Opin Ther Pat. 2014 May;24(5):597-602.
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