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USP8-IN-2

CAS No. 2477651-11-7

USP8-IN-2( —— )

Catalog No. M36043 CAS No. 2477651-11-7

USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D. USP8-IN-2 is a potential compound for the treatment of cancer and viral infections.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

USP8-IN-2
Note

Research use only, not for human use.
Brief Description

USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D. USP8-IN-2 is a potential compound for the treatment of cancer and viral infections.
Description

USP8-IN-2 (Compd U52) is a deubiquitinase USP8 inhibitor with an IC50 value of 6.0 μM. USP8-IN-2 also inhibits the proliferation of H1957 cells with an GI50 value of 24.93 μM, respectively.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

——
Indication

——

Chemical Information

CAS Number

2477651-11-7
Formula Weight

444.9
Molecular Formula

C19H20ClF3N4OS
Purity

>98% (HPLC)
Solubility

——
SMILES

C(F)(F)(F)C1=NC(=CC=C1)N2CCC(NC(NC3=C(OC)C=CC(Cl)=C3)=S)CC2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Li zhiyun, et al. Preparing method and application of USP8 inhibitor: China, CN111138358 A. 2020-05-12.

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