ULK-100 ( ULK100 )

Catalog No. M16933 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

ULK-100
Note

Research use only, not for human use.
Brief Description

ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM.
Description

ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM; reduces Ser15 phosphorylation in a concentration-dependent manner in cell-based assay (EC50=83 nM), which is more potent than SBI-0206965 showing a cellular EC50 of 2.4 uM; displays desirable kinome selectivity profile.
Synonyms

ULK100
Pathway

Autophagy
Target

ULK
Recptor

ULK
Research Area

——
Indication

——

CAS Number

--
Formula Weight

599.72
Molecular Formula

C31H36F3N5O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC(C2=C3N=CC(OCCN4CCCCC4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F
Chemical Name

(S)-N-(3-ethyl-1,1,1-trifluoropentan-2-yl)-4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

1. Martin KR, et al. iScience. 2018 Oct 26;8:74-84. doi: 10.1016/j.isci.2018.09.012.

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