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ULK-100
CAS No. ——
ULK-100( ULK100 )
Catalog No. M16933 CAS No. ——
ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameULK-100
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NoteResearch use only, not for human use.
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Brief DescriptionULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM.
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DescriptionULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM; reduces Ser15 phosphorylation in a concentration-dependent manner in cell-based assay (EC50=83 nM), which is more potent than SBI-0206965 showing a cellular EC50 of 2.4 uM; displays desirable kinome selectivity profile.
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In Vitro——
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In Vivo——
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SynonymsULK100
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PathwayAutophagy
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TargetULK
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RecptorULK
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight599.717
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Molecular FormulaC31H36F3N5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=CC(C2=C3N=CC(OCCN4CCCCC4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F
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Chemical Name(S)-N-(3-ethyl-1,1,1-trifluoropentan-2-yl)-4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Martin KR, et al. iScience. 2018 Oct 26;8:74-84. doi: 10.1016/j.isci.2018.09.012.
molnova catalog
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