BL-918 ( BL918 )

Catalog No. M13336 CAS No. 2101517-69-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

BL-918
Note

Research use only, not for human use.
Brief Description

BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM).
Description

BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM), induces autophagy via the ULK complex in SH-SY5Y cells; displays a cytoprotective effect on MPP+-treated SH-SY5Y cells, as well as protected against MPTP-induced motor dysfunction and loss of dopaminergic neurons by targeting ULK1-modulated autophagy in mouse models of PD.
Synonyms

BL918
Pathway

Autophagy
Target

ULK
Recptor

ULK
Research Area

——
Indication

——

CAS Number

2101517-69-3
Formula Weight

533.44
Molecular Formula

C23H15F8N3OS
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC1=CC=C(F)C=C1F)[C@H](NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=S)C3=CC=CC=C3
Chemical Name

(R)-2-(3-(3,5-Bis(trifluoromethyl)phenyl)thioureido)-N-(2,4-difluorophenyl)-2-phenylacetamide

1. Ouyang L, et al. J Med Chem. 2018 Apr 12;61(7):2776-2792.

Calculator

molnova catalog