LYN-1604 ( LYN1604 )

Catalog No. M13261 CAS No. 2088939-99-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LYN-1604
Note

Research use only, not for human use.
Brief Description

LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells).
Description

LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells), displays a good effect on ULK1 activation with an EC50 of 18.94 nM; induces cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells; induces cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis; inhibits the growth of xenograft TNBC.
Synonyms

LYN1604
Pathway

Autophagy
Target

ULK
Recptor

ULK1
Research Area

Other Indications
Indication

——

CAS Number

2088939-99-3
Formula Weight

584.63
Molecular Formula

C33H43Cl2N3O2
Purity

>98% (HPLC)
Solubility

DMSO: 46 mg/mL (78.7 mM); Water: 90 mg/mL (153.9 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CC(C)CN(CC(C)C)CC(=O)N1CCN(CC1)CC(C2=C(C=C(C=C2)Cl)Cl)OCC3=CC4=CC=CC=C4C=C3
Chemical Name

Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-

1. Zhang L, et al. Chem Sci. 2017 Apr 1;8(4):2687-2701.
2. Ouyang L, et al. Autophagy. 2017 Apr 3;13(4):777-778.

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