Alogliptin ( Alogliptin )

Catalog No. M17613 CAS No. 850649-61-5

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Product Name

Alogliptin
Note

Research use only, not for human use.
Brief Description

Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.
Description

Alogliptin is a DPP-4 inhibitor used for the treatment of Type 2 diabetes. Like other members of the gliptin class, it causes little or no weight gain, exhibits relatively little risk of causing hypoglycemia, and exhibits relatively modest glucose-lowering activity. Alogliptin and other gliptins are commonly used in combination with metformin in patients whose diabetes cannot adequately be controlled with metformin alone.
Synonyms

Alogliptin
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

DPP-4
Research Area

Metabolic Disease
Indication

——

CAS Number

850649-61-5
Formula Weight

339.39
Molecular Formula

C18H21N5O2
Purity

98%
Solubility

——
SMILES

CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=CC=CC=C2C#N)C1=O
Chemical Name

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile

1. Feng J, et al. J Med Chem, 2007, 50(10), 2297-2300.

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