
Triptolide
CAS No. 38748-32-2
Triptolide( PG490 | PG 490 | PG-490 )
Catalog No. M14333 CAS No. 38748-32-2
The active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 88 | In Stock |
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10MG | 128 | In Stock |
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25MG | 296 | In Stock |
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50MG | 444 | In Stock |
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100MG | 526 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameTriptolide
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NoteResearch use only, not for human use.
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Brief DescriptionThe active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism.
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DescriptionThe active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism; arrests cellular proliferation and attenuates overall cyst formation by restoring Ca(2+) signaling in a murine model of ADPKD; also covalently binds to human XPB (ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II-mediated transcription; inhibits TAK1 kinase activity by interfering with the formation of the TAK1-TAB1 complex in macrophages.Pancreatic Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsPG490 | PG 490 | PG-490
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PathwayNF-κB
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TargetTAK1
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Recptorheatshockfactor(HSF1)(inALLcelllines)|Mdm2
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Research AreaCancer
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IndicationPancreatic Cancer
Chemical Information
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CAS Number38748-32-2
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Formula Weight360.401
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Molecular FormulaC20H24O6
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 33 mg/mL
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SMILESO=C(OC1)C2=C1[C@@](C[C@H]3[C@]4(O3)[C@@]5(O6)[C@@H]6[C@H](O7)[C@@]7(C(C)C)[C@H]4O)([H])[C@]5(C)CC2
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Chemical NameTrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Leuenroth SJ, et al. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4389-94.
2. Titov DV, et al. Nat Chem Biol. 2011 Mar;7(3):182-8.
3. Lu Y, et al. Chem Biol. 2014 Feb 20;21(2):246-56.
molnova catalog



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