Triptolide

CAS No. 38748-32-2

Triptolide( PG490 | PG 490 | PG-490 )

Catalog No. M14333 CAS No. 38748-32-2

The active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 88 In Stock
10MG 128 In Stock
25MG 296 In Stock
50MG 444 In Stock
100MG 526 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Triptolide
  • Note
    Research use only, not for human use.
  • Brief Description
    The active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism.
  • Description
    The active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism; arrests cellular proliferation and attenuates overall cyst formation by restoring Ca(2+) signaling in a murine model of ADPKD; also covalently binds to human XPB (ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II-mediated transcription; inhibits TAK1 kinase activity by interfering with the formation of the TAK1-TAB1 complex in macrophages.Pancreatic Cancer Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PG490 | PG 490 | PG-490
  • Pathway
    NF-κB
  • Target
    TAK1
  • Recptor
    heatshockfactor(HSF1)(inALLcelllines)|Mdm2
  • Research Area
    Cancer
  • Indication
    Pancreatic Cancer

Chemical Information

  • CAS Number
    38748-32-2
  • Formula Weight
    360.401
  • Molecular Formula
    C20H24O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 33 mg/mL
  • SMILES
    O=C(OC1)C2=C1[C@@](C[C@H]3[C@]4(O3)[C@@]5(O6)[C@@H]6[C@H](O7)[C@@]7(C(C)C)[C@H]4O)([H])[C@]5(C)CC2
  • Chemical Name
    Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Leuenroth SJ, et al. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4389-94. 2. Titov DV, et al. Nat Chem Biol. 2011 Mar;7(3):182-8. 3. Lu Y, et al. Chem Biol. 2014 Feb 20;21(2):246-56.
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