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(5Z)-7-Oxozeaenol

CAS No. 66018-38-0

(5Z)-7-Oxozeaenol( 5Z-7-oxozeaenol )

Catalog No. M15511 CAS No. 66018-38-0

(5Z)-7-Oxozeaenol is a potent and selective TAK1 inhibitor with IC50 of 8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    (5Z)-7-Oxozeaenol
  • Note
    Research use only, not for human use.
  • Brief Description
    (5Z)-7-Oxozeaenol is a potent and selective TAK1 inhibitor with IC50 of 8 nM.
  • Description
    (5Z)-7-Oxozeaenol is a potent and selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively; inhibits IL-1-induced activation of NF-κB (IC50 = 83 nM) and JNK/p38; also inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    5Z-7-oxozeaenol
  • Pathway
    NF-κB
  • Target
    TAK1
  • Recptor
    TAK1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    66018-38-0
  • Formula Weight
    362.37
  • Molecular Formula
    C19H22O7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1CC=CC(=O)C(C(CC=CC2=C(C(=CC(=C2)OC)O)C(=O)O1)O)O
  • Chemical Name
    (3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Windheim M, et al. Biochem J. 2007 Jun 1;404(2):179-90. 2. Choo MK, et al. Mol Cancer Ther. 2006 Dec;5(12):2970-6. 3. Ninomiya-Tsuji J, et al. J Biol Chem. 2003 May 16;278(20):18485-90.
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