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PF-05381941

CAS No. 1474022-02-0

PF-05381941( PF 05381941 | PF05381941 )

Catalog No. M12029 CAS No. 1474022-02-0

PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PF-05381941
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively.
  • Description
    PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases; inhibits LPS-stimulated release of TNF-α from human peripheral mononuclear cells with IC50 of 8 nM.
  • In Vitro
    PF-05381941 inhibits LPS-stimulated release of TNF-αfrom human peripheralmononuclear (PMN) cells with an IC50 of 8 nM.
  • In Vivo
    ——
  • Synonyms
    PF 05381941 | PF05381941
  • Pathway
    NF-κB
  • Target
    TAK1
  • Recptor
    TAK1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1474022-02-0
  • Formula Weight
    466.545
  • Molecular Formula
    C27H26N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (214.35 mM)
  • SMILES
    ——
  • Chemical Name
    1-(3-(tert-butyl)-1-(3-cyanophenyl)-1H-pyrazol-5-yl)-3-(3-methyl-4-(pyridin-4-yloxy)phenyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kilty I, et al. Future Med Chem. 2015;7(1):23-33.
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