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PF-05381941
CAS No. 1474022-02-0
PF-05381941( PF 05381941 | PF05381941 )
Catalog No. M12029 CAS No. 1474022-02-0
PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 202 | Get Quote |
|
| 50MG | 1026 | Get Quote |
|
| 100MG | 1638 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF-05381941
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NoteResearch use only, not for human use.
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Brief DescriptionPF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively.
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DescriptionPF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases; inhibits LPS-stimulated release of TNF-α from human peripheral mononuclear cells with IC50 of 8 nM.
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In VitroPF-05381941 inhibits LPS-stimulated release of TNF-αfrom human peripheralmononuclear (PMN) cells with an IC50 of 8 nM.
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In Vivo——
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SynonymsPF 05381941 | PF05381941
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PathwayNF-κB
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TargetTAK1
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RecptorTAK1
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Research Area——
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Indication——
Chemical Information
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CAS Number1474022-02-0
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Formula Weight466.545
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Molecular FormulaC27H26N6O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (214.35 mM)
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SMILES——
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Chemical Name1-(3-(tert-butyl)-1-(3-cyanophenyl)-1H-pyrazol-5-yl)-3-(3-methyl-4-(pyridin-4-yloxy)phenyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kilty I, et al. Future Med Chem. 2015;7(1):23-33.
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