Trabectedin ( Ecteinascidin-743;ET-743;Ecteinascidin )

Catalog No. M10525 CAS No. 114899-77-3

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Product Name

Trabectedin
Note

Research use only, not for human use.
Brief Description

Trabectedin (Ecteinascidin-743, ET-743, Ecteinascidin)is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata that shows remarkably anticancer activity in a variety of in vitro and in vivo systems.
Description

Trabectedin (Ecteinascidin-743, ET-743, Ecteinascidin)is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata that shows remarkably anticancer activity in a variety of in vitro and in vivo systems; a DNA minor groove, guanine-specific alkylating agent; shows hign potency against ovarian carcinoma xenografts.Ovarian Cancer Approved
Synonyms

Ecteinascidin-743;ET-743;Ecteinascidin
Pathway

Cell Cycle/DNA Damage
Target

DNA Alkylator
Recptor

DNA Alkylator
Research Area

Cancer
Indication

Ovarian Cancer

CAS Number

114899-77-3
Formula Weight

761.84
Molecular Formula

C39H43N3O11S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=C(OC)C(O)=C2C3[C@@H]4[C@@H]5C6=C(C7=C(OCO7)C(C)=C6OC(C)=O)[C@@H](COC(C8(C9=CC(OC)=C(O)C=C9CCN8)CS5)=O)N4C(O)C(CC2=C1)N3C
Chemical Name

Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (1'R,6R,6aR,7R,13S,14S,16

1. Pommier Y, et al. Biochemistry. 1996 Oct 15;35(41):13303-9.
2. Valoti G, et al. Clin Cancer Res. 1998 Aug;4(8):1977-83.

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