Alchemix ( ZP281M )

Catalog No. M13856 CAS No. 281189-60-4

A dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Alchemix
Note

Research use only, not for human use.
Brief Description

A dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.
Description

A dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer; shows excellent antitumor activity in Adriamycin-resistant (2780AD) and cisplatin-resistant cell lines (IC50=19 nM) in vitro and in vivo; induces cell death independently of ATM and p53.
Synonyms

ZP281M
Pathway

Cell Cycle/DNA Damage
Target

DNA Alkylator
Recptor

DNA Alkylator
Research Area

——
Indication

——

Chemical Information

CAS Number

281189-60-4
Formula Weight

509.43
Molecular Formula

C24H30Cl2N4O4
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

1-((2-(bis(2-chloroethyl)amino)ethyl)amino)-4-((2-(dimethylamino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Pors K, et al. Mol Cancer Ther. 2003 Jul;2(7):607-10.
2. Pors K, et al. J Med Chem. 2004 Mar 25;47(7):1856-9.
3. Thomas A, et al. Oncogene. 2015 Jun;34(25):3336-48.

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