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Home - Products - Cell Cycle/DNA Damage - DNA Alkylator - Alchemix

Alchemix

CAS No. 281189-60-4

Alchemix ( ZP281M )

Catalog No. M13856 CAS No. 281189-60-4

A dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Alchemix
  • Note
    Research use only, not for human use.
  • Brief Description
    A dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.
  • Description
    A dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer; shows excellent antitumor activity in Adriamycin-resistant (2780AD) and cisplatin-resistant cell lines (IC50=19 nM) in vitro and in vivo; induces cell death independently of ATM and p53.
  • Synonyms
    ZP281M
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Alkylator
  • Recptor
    DNA Alkylator
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    281189-60-4
  • Formula Weight
    509.43
  • Molecular Formula
    C24H30Cl2N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    1-((2-(bis(2-chloroethyl)amino)ethyl)amino)-4-((2-(dimethylamino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pors K, et al. Mol Cancer Ther. 2003 Jul;2(7):607-10.
2. Pors K, et al. J Med Chem. 2004 Mar 25;47(7):1856-9.
3. Thomas A, et al. Oncogene. 2015 Jun;34(25):3336-48.
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