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Clofazimine

CAS No. 2030-63-9

Clofazimine( NSC 141046 )

Catalog No. M13158 CAS No. 2030-63-9

Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Clofazimine
  • Note
    Research use only, not for human use.
  • Brief Description
    Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.
  • Description
    Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female BALB/c mice (age 6–8 weeks, mass 18–20 g)Dosage:100, 50, 25, 12.5, 6.25, 3.125 or 1.5625 mg/kgAdministration:Oral gavage (p.o.), once per day for 14 dResult:Exhibited an increase of the lung bacterial load during the first 7 days of treatment, and decreased the CFU counts in the lungs of mice after 10 days of treatment. Significantly declined the lung CFU counts in 100 or 50 mg/ kg group at 14th day.
  • Synonyms
    NSC 141046
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Alkylator
  • Recptor
    DNA| CzcO-like
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    2030-63-9
  • Formula Weight
    473.4
  • Molecular Formula
    C27H22Cl2N4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 5 mg/mL (10.56 mM)
  • SMILES
    CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
  • Chemical Name
    N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cholo MC, et al. J Antimicrob ChemOthers. 2006 Jan;57(1):79-84.
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