Toreforant ( JNJ-38518168;JNJ38518168 )

Catalog No. M16809 CAS No. 952494-46-1

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Product Name

Toreforant
Note

Research use only, not for human use.
Brief Description

Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM.
Description

Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors; JNJ-38518168 acts as an antagonist in all species tested and inhibits histamine-induced eosinophil shape change in vitro; demonstrates anti-inflammatory activities in mouse models of asthma and arthritis.Rheumatoid Arthritis Phase 2 Clinical
Synonyms

JNJ-38518168;JNJ38518168
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Histamine Receptor
Research Area

Inflammation/Immunology
Indication

Rheumatoid Arthritis

CAS Number

952494-46-1
Formula Weight

392.55
Molecular Formula

C23H32N6
Purity

>98% (HPLC)
Solubility

——
SMILES

CN1CCC(CCCNC2=NC=C(C3=NC4=C(C)C=C(C)C=C4N3)C(C)=N2)CC1
Chemical Name

5-(4,6-dimethyl-1H-benzimidazol-2-yl)-4-methyl-N-[3-(1-methylpiperidin-4-yl)propyl]pyrimidin-2-amine

1. Thurmond RL, et al. J Rheumatol. 2016 Sep;43(9):1637-42.

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