Cart
sales@molnova.com
Toreforant
CAS No. 952494-46-1
Toreforant ( JNJ-38518168;JNJ38518168 )
Catalog No. M16809 CAS No. 952494-46-1
Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 484 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameToreforant
-
NoteResearch use only, not for human use.
-
Brief DescriptionToreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM.
-
DescriptionToreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors; JNJ-38518168 acts as an antagonist in all species tested and inhibits histamine-induced eosinophil shape change in vitro; demonstrates anti-inflammatory activities in mouse models of asthma and arthritis.Rheumatoid Arthritis Phase 2 Clinical
-
SynonymsJNJ-38518168;JNJ38518168
-
PathwayGPCR/G Protein
-
TargetHistamine Receptor
-
RecptorHistamine Receptor
-
Research AreaInflammation/Immunology
-
IndicationRheumatoid Arthritis
Chemical Information
-
CAS Number952494-46-1
-
Formula Weight392.55
-
Molecular FormulaC23H32N6
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCN1CCC(CCCNC2=NC=C(C3=NC4=C(C)C=C(C)C=C4N3)C(C)=N2)CC1
-
Chemical Name5-(4,6-dimethyl-1H-benzimidazol-2-yl)-4-methyl-N-[3-(1-methylpiperidin-4-yl)propyl]pyrimidin-2-amine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Thurmond RL, et al. J Rheumatol. 2016 Sep;43(9):1637-42.
molnova catalog
related products
-
Betahistine mesylate
Betahistine is an antivertigo drug first used for treating vertigo assosicated with Ménière’s disease.
-
Propionyl-L-carnitin...
Levocarnitine propionate hcl is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.
-
Sodium butanoate
Sodium Butyrate(Butanoic acid sodium salt) has been reported to cause hyperacetylation of histones due to its role as a histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively).
