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Toreforant

CAS No. 952494-46-1

Toreforant ( JNJ-38518168;JNJ38518168 )

Catalog No. M16809 CAS No. 952494-46-1

Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Toreforant
  • Note
    Research use only, not for human use.
  • Brief Description
    Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM.
  • Description
    Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors; JNJ-38518168 acts as an antagonist in all species tested and inhibits histamine-induced eosinophil shape change in vitro; demonstrates anti-inflammatory activities in mouse models of asthma and arthritis.Rheumatoid Arthritis Phase 2 Clinical
  • Synonyms
    JNJ-38518168;JNJ38518168
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    Rheumatoid Arthritis

Chemical Information

  • CAS Number
    952494-46-1
  • Formula Weight
    392.55
  • Molecular Formula
    C23H32N6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1CCC(CCCNC2=NC=C(C3=NC4=C(C)C=C(C)C=C4N3)C(C)=N2)CC1
  • Chemical Name
    5-(4,6-dimethyl-1H-benzimidazol-2-yl)-4-methyl-N-[3-(1-methylpiperidin-4-yl)propyl]pyrimidin-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Thurmond RL, et al. J Rheumatol. 2016 Sep;43(9):1637-42.
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