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Tolnaftate
CAS No. 2398-96-1
Tolnaftate( NSC 233648 | SCH 10144 )
Catalog No. M13694 CAS No. 2398-96-1
Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1G | 45 | In Stock |
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Biological Information
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Product NameTolnaftate
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NoteResearch use only, not for human use.
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Brief DescriptionTolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.
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DescriptionTolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.(In Vitro):Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid.
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In VitroTolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid.
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In Vivo——
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SynonymsNSC 233648 | SCH 10144
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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RecptorSmoothened
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number2398-96-1
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Formula Weight307.42
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Molecular FormulaC19H17NOS
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Purity>98% (HPLC)
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SolubilityDMSO: 62 mg/mL (201.68 mM)
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SMILESS=C(OC1=CC=C2C=CC=CC2=C1)N(C)C3=CC=CC(C)=C3
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Chemical NameO-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Barrett-Bee K, Dixon G. Acta Biochim Pol. 1995;42(4):465-79.
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