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Purmorphamine
CAS No. 483367-10-8
Purmorphamine( Purmorphamine )
Catalog No. M14618 CAS No. 483367-10-8
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 130 | In Stock |
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| 50MG | 267 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePurmorphamine
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NoteResearch use only, not for human use.
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Brief DescriptionPurmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
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DescriptionPurmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
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In VitroPurmorphamine (GMP) (1.5 μM, 1 week) can generate embryoid bodies (EBs) from human iPS cells (hiPS2) and hESCs (HSF1).Purmorphamine (GMP) (1.5 μM) converts hPSCs to NKX2-1 positive MGE cells.Purmorphamine (GMP) (2 μM, day 28-35) promotes ventralization of the brain spheroids in differentiation process from hiPSCs. Purmorphamine (GMP) (1 μM) together with retinoic acid (RA, 2 μM) promotes hiPSC differentiation into functional neural tissue, indicated by the expression of neuronal marker β-tubulin III (βT-III).Purmorphamine (GMP) (day5-7) induces hESCs differentiation into dopaminergic (DA) neurons.
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In Vivo——
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SynonymsPurmorphamine
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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RecptorSmoothened
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number483367-10-8
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Formula Weight520.62
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Molecular FormulaC31H32N6O2
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Purity>98% (HPLC)
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SolubilityDMSO: 4 mg/mL warmed (7.68 mM)
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SMILESN1(C2CCCCC2)C=NC3=C(NC4=CC=C(N5CCOCC5)C=C4)N=C(OC6=C7C=CC=CC7=CC=C6)N=C13
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Chemical Name9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Faghihi F, Biomed PharmacOthers, 2012, 3322(12).
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