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Tofogliflozin

CAS No. 903565-83-3

Tofogliflozin( CSG452 | CSG-452 )

Catalog No. M16493 CAS No. 903565-83-3

Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Tofogliflozin
  • Note
    Research use only, not for human use.
  • Brief Description
    Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
  • Description
    Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively; displays high selectivity over human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1; increases renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats, also improves postprandial glucose excursion; reduces glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test in vivo.Diabetes Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CSG452 | CSG-452
  • Pathway
    GPCR/G Protein
  • Target
    SGLT
  • Recptor
    SGLT
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    903565-83-3
  • Formula Weight
    386.444
  • Molecular Formula
    C22H26O6
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCC1=CC=C(C=C1)CC2=CC3=C(COC34C(C(C(C(O4)CO)O)O)O)C=C2
  • Chemical Name
    Spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol, 6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-, (1S,3'R,4'S,5'S,6'R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Suzuki M, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701. 2. Ohtake Y, et al. J Med Chem. 2012 Sep 13;55(17):7828-40. 3. Nagata T, et al. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23. 4. Nagata T, et al. Br J Pharmacol. 2013 Oct;170(3):519-31.
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