Thiazovivin

CAS No. 1226056-71-8

Thiazovivin( Tzv )

Catalog No. M10866 CAS No. 1226056-71-8

Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of 0.5 μM, promotes hESC survival after single-cell dissociation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 40 In Stock
5MG 61 In Stock
10MG 105 In Stock
25MG 200 In Stock
50MG 361 In Stock
100MG 537 In Stock
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Biological Information

  • Product Name
    Thiazovivin
  • Note
    Research use only, not for human use.
  • Brief Description
    Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of 0.5 μM, promotes hESC survival after single-cell dissociation.
  • Description
    Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of 0.5μM, promotes hESC survival after single-cell dissociation.
  • In Vitro
    Thiazovivin (GMP) (0.5 ?μM, at 1 day) promotes rapid and efficient reprogramming of mouse tail tip and embryonic fibroblasts into iPSCs.Thiazovivin (GMP) enhances the efficiency in reprograming endometrial adult stromal cells to iPSCs.Thiazovivin (GMP) (2 μM) induces iPSCs and induced neural stem cells (iNSCs) from human urine cells (UCs).Thiazovivin (GMP) (2 μM, for the first 24 h) improves growth rate of hiPSCs.Thiazovivin (GMP) (0.5 μM) together with SB431542 and PD0325901 promotes iPSC reprogramming by regulating cell-cell interactions.
  • In Vivo
    ——
  • Synonyms
    Tzv
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ROCK
  • Recptor
    ROCK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1226056-71-8
  • Formula Weight
    311.36
  • Molecular Formula
    C15H13N5OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 15 mg/mL (48.17 mM)
  • SMILES
    O=C(C1=CSC(NC2=NC=NC=C2)=N1)NCC3=CC=CC=C3
  • Chemical Name
    N-(phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yue Xu, et al. PNAS, May 4, 2010 vol. 107 no. 18 8129-8134
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