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Chroman 1
CAS No. 1273579-40-0
Chroman 1( —— )
Catalog No. M26648 CAS No. 1273579-40-0
Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 183 | In Stock |
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| 5MG | 163 | In Stock |
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| 10MG | 264 | In Stock |
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| 25MG | 454 | In Stock |
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| 50MG | 667 | In Stock |
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| 100MG | 918 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameChroman 1
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NoteResearch use only, not for human use.
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Brief DescriptionChroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).
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DescriptionChroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).(In Vitro):Chroman 1 showed inhibitory activities against MRCK (IC50: 150 nM). However, it has no effect on PKA (IC50, > 20000 nM) or AKT1 (IC50, > 20000 nM).
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In VitroApoptosis Analysis Cell Line:hESCs (human pluripotent stem cells) (WA09)Concentration:50 nMIncubation Time:0-12 h or 24 h Result:Reduced the number of apoptotic cells, reduced caspase-3/7 activation.Western Blot Analysis Cell Line:hESCs (human pluripotent stem cells) (WA09)Concentration:50 nM Incubation Time:24 h Result:Partially inhibited caspase-3 activation.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetROCK
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Recptorinflammation
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Research Area——
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Indication——
Chemical Information
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CAS Number1273579-40-0
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Formula Weight436.512
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Molecular FormulaC24H28N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 50 mg/mL (114.55 mM)
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SMILESCOc1ccc2OC[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Y-33075 dihydrochlor...
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Y-33075 (Y-39983) is a potent inhibitor of ROCK(IC50 of 3.6 nM). Y-33075 also inhibits PKC and CaMKII more potently than Y-27632(IC50s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively), whereas the IC50s of Y-27632 and Y-33075 for CaMKII are 26 μM and 0.81 μM, respectively.
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Cotosudil
Cotosudil is a ROCK kinase inhibitor with antihypertensive activity and is used to treat or prevent diseases or conditions caused by cataracts, cardiovascular or neurodegenerative diseases or nerve damage.
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Cucurbitacin A
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
