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Verosudil
CAS No. 1414854-42-4
Verosudil( AR-12286 )
Catalog No. M11719 CAS No. 1414854-42-4
Verosudil (AR-12286) is a potent ROCK inhibitor (Ki=0.2 nM) that effectively lowers intraocular pressure (IOP) in animal models and human subjects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 164 | In Stock |
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| 5MG | 150 | In Stock |
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| 10MG | 244 | In Stock |
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| 25MG | 391 | In Stock |
|
| 50MG | 540 | In Stock |
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| 100MG | 714 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVerosudil
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NoteResearch use only, not for human use.
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Brief DescriptionVerosudil (AR-12286) is a potent ROCK inhibitor (Ki=0.2 nM) that effectively lowers intraocular pressure (IOP) in animal models and human subjects.
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DescriptionVerosudil (AR-12286) is a potent ROCK inhibitor (Ki=0.2 nM) that effectively lowers intraocular pressure (IOP) in animal models and human subjects Other Indication Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAR-12286
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PathwayCell Cycle/DNA Damage
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TargetROCK
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RecptorROCK
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1414854-42-4
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Formula Weight327.402
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Molecular FormulaC17H17N3O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 16.67 mg/mL (50.92 mM)
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SMILESCN(C)C(C1=CSC=C1)C(=O)NC2=CC3=C(C=C2)C(=O)NC=C3
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Chemical Name2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80.
2. Kopczynski C, et al. Br J Ophthalmol. 2013 May;97(5):567-72.
3. Williams RD, et al. Am J Ophthalmol. 2011 Nov;152(5):834-41.e1.
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