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Thevetiaflavone

CAS No. 29376-68-9

Thevetiaflavone ( Apigenin-5-methyl ether; 2-Genistein-5-methyl ether )

Catalog No. M26581 CAS No. 29376-68-9

Thevetiaflavone could up-regulate the expression of Bcl 2 and down-regulate that of Bax and caspase 3.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Thevetiaflavone
  • Note
    Research use only, not for human use.
  • Brief Description
    Thevetiaflavone could up-regulate the expression of Bcl 2 and down-regulate that of Bax and caspase 3.
  • Description
    Thevetiaflavone could up-regulate the expression of Bcl 2 and down-regulate that of Bax and caspase 3.(In Vitro):Thevetiaflavone reduces ROS overproduction and ameliorates ROS-mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and opening of mitochondrial permeability transition pores, thereby reducing intracellular Ca2+ levels. Thevetiaflavone up-regulates the expression of Bcl-2, down-regulates the expression of Bax and caspase-3 and increases the activity of caspase-3 to inhibit the apoptosis of PC12 cells.
  • Synonyms
    Apigenin-5-methyl ether; 2-Genistein-5-methyl ether
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    5-Lipoxygenase; prostaglandin synthetase (PGS)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    29376-68-9
  • Formula Weight
    284.3
  • Molecular Formula
    C16H12O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1cc(O)cc2oc(cc(=O)c12)-c1ccc(O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Katsumi I, et al. Studies on styrene derivatives. I. Synthesis and antiinflammatory activities of alpha-benzylidene-gamma-butyrolactone derivatives. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):121-9.
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