BT2
CAS No. 34576-94-8
BT2 ( —— )
Catalog No. M22491 CAS No. 34576-94-8
BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
10MG | 35 | In Stock |
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25MG | 52 | In Stock |
|
50MG | 65 | In Stock |
|
100MG | 95 | In Stock |
|
500MG | 230 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameBT2
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NoteResearch use only, not for human use.
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Brief DescriptionBT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM.
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DescriptionBT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC).BT2 treatment reduces the protein levels of BDK in kidneys and heart[1]. The -fold activation of BCKDC activity in the above tissues correlates with decreased phosphorylation in heart, muscle, and kidney after the long term BT2 treatment. BT2 (20 mg/kg/day; intraperitoneal injection; daily; for 7 days; C57BL/6J male mice) treatment robustly enhances BCKDC activity in the heart (12.3-fold) compared with the vehicle-treated animals. Less activation is obtained in muscle and kidney at 3.6- and 3.8-fold, respectively.
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Synonyms——
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBDK;Mcl-1
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Research Area——
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Indication——
Chemical Information
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CAS Number34576-94-8
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Formula Weight247.1
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Molecular FormulaC9H4Cl2O2S
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL (337.23 mM; Need ultrasonic)
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SMILESOC(=O)c1sc2cc(Cl)ccc2c1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tso SC, et al. Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase. J Biol Chem. 2014 Jul 25;289(30):20583-93.
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