AMG-176 ( AMG 176;AMG176 )

Catalog No. M12935 CAS No. 1883727-34-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

AMG-176
Note

Research use only, not for human use.
Brief Description

AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity and selectivity to the BH3-binding groove of Mcl-1.
Description

AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity and selectivity to the BH3-binding groove of Mcl-1; disrupts the interaction between Mcl-1 and Bak, leading to downstream activation of the intrinsic apoptosis pathway in a cell based split-luciferase complementation assay; shows robust anti-tumor activity in Mcl-1 dependent cancer models; orally bioavailable.
Synonyms

AMG 176;AMG176
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

Cancer
Indication

——

CAS Number

1883727-34-1
Formula Weight

613.21
Molecular Formula

C33H41ClN2O5S
Purity

>98% (HPLC)
Solubility

DMSO : 62.5 mg/mL 101.92 mM
SMILES

O=C(N1)C2=CC(N(C[C@H]3[C@@H](CC3)[C@@H](OC)/C=C/C[C@H](C)[C@@H](C)S1(=O)=O)C4)=C(C=C2)OC[C@@]54CCCC6=CC(Cl)=CC=C65
Chemical Name

Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-

1. Sean R. Caenepeel, et al. AACR Annual Meeting 2017; April 1-5, 2017.

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