AMG-176

Research use only, not for human use.

AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity and selectivity to the BH3-binding groove of Mcl-1.

AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity and selectivity to the BH3-binding groove of Mcl-1; disrupts the interaction between Mcl-1 and Bak, leading to downstream activation of the intrinsic apoptosis pathway in a cell based split-luciferase complementation assay; shows robust anti-tumor activity in Mcl-1 dependent cancer models; orally bioavailable.

AMG 176;AMG176

Angiogenesis

Bcl-2

Bcl-2

Cancer

——

1883727-34-1

613.21

C33H41ClN2O5S

>98% (HPLC)

DMSO : 62.5 mg/mL 101.92 mM

O=C(N1)C2=CC(N(C[C@H]3[C@@H](CC3)[C@@H](OC)/C=C/C[C@H](C)[C@@H](C)S1(=O)=O)C4)=C(C=C2)OC[C@@]54CCCC6=CC(Cl)=CC=C65

Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-

(-20℃)

With Ice Pack

≥ 2 years