LC3-mHTT-IN-AN1 ( —— )

Catalog No. M21755 CAS No. 486443-73-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

LC3-mHTT-IN-AN1
Note

Research use only, not for human use.
Brief Description

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.
Description

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
In Vitro

LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons.
In Vivo

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Synonyms

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Pathway

Autophagy
Target

Autophagy
Recptor

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Research Area

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Indication

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CAS Number

486443-73-6
Formula Weight

411.04
Molecular Formula

C??H?Br?NO?
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL (304.11 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)
SMILES

BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
Chemical Name

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1. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.

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