Talquetamab( —— )

Catalog No. M36758 CAS No. 2226212-40-2

Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	439	Get Quote
5MG	687	Get Quote
10MG	1102	Get Quote
25MG	1582	Get Quote
50MG	2134	Get Quote
100MG	2817	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

Talquetamab
Note

Research use only, not for human use.
Brief Description

Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.
Description

Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity.
In Vitro

——
In Vivo

Animal Model:Female NSG mice with H929 cells Dosage:0.1-10 μg (0.005 mg/kg) Administration:Subcutaneous injection; on days 0, 3, 5, 7, and 10 Result:Completely blocked tumor formation at 1 μg and 10 μg doses. Animal Model:Female NSG mice with human MM cells Dosage:0.1-50 μg (0.005 mg/kg) Administration:Intravenous injection; on days 15, 18, 22, 24, 29, 32, and 36 Result:Significantly inhibited tumor growth by 65% at the dose of 1μg and showed significant anti-tumor activity at 10 and 50 μg with complete tumor regression.
Synonyms

——
Pathway

GPCR/G Protein
Target

Dopamine Receptor
Recptor

Dopamine Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

2226212-40-2
Formula Weight
Molecular Formula

——
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Christie P M Verkleij, et al. Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma. Blood Adv. 2021 Apr 27;5(8):2196-2215.?

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks