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Talquetamab

CAS No. 2226212-40-2

Talquetamab( —— )

Catalog No. M36758 CAS No. 2226212-40-2

Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 439 Get Quote
5MG 687 Get Quote
10MG 1102 Get Quote
25MG 1582 Get Quote
50MG 2134 Get Quote
100MG 2817 Get Quote
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Biological Information

  • Product Name
    Talquetamab
  • Note
    Research use only, not for human use.
  • Brief Description
    Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.
  • Description
    Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female NSG mice with H929 cells Dosage:0.1-10 μg (0.005 mg/kg) Administration:Subcutaneous injection; on days 0, 3, 5, 7, and 10 Result:Completely blocked tumor formation at 1 μg and 10 μg doses. Animal Model:Female NSG mice with human MM cells Dosage:0.1-50 μg (0.005 mg/kg) Administration:Intravenous injection; on days 15, 18, 22, 24, 29, 32, and 36 Result:Significantly inhibited tumor growth by 65% at the dose of 1μg and showed significant anti-tumor activity at 10 and 50 μg with complete tumor regression.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2226212-40-2
  • Formula Weight
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Christie P M Verkleij, et al. Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma. Blood Adv. 2021 Apr 27;5(8):2196-2215.?
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