5-HT6/7 antagonist 1

Research use only, not for human use.

5-HT6/7 antagonist 1 is a dual 5-HT6/7/2A and D2 receptor antagonist used in the study of dementia and Alzheimer's disease.

5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A andD2 receptors, without interacting with M1 receptors and hERG channels.

Targeting 5-HT6 and/ or 5-HT7 receptors with antagonist drugs could constitute a promising strategy for treating symptoms of BPSD while avoiding some of the side effects of current antipsychotic drugs. Nevertheless, due to the complex pathology of dementia and accompanying behavioral and psychological symptoms, it seems unlikely that focusing on a single therapeutic target would be sufficient to provide adequate clinical benefit, and it is likely that successful development of novel anti-BPSD agents should involve a “designed” multifactorial approach..

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GPCR/G Protein

Dopamine Receptor

Dopamine Receptor | 5-HT Receptor

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131999-28-5

393.41

C22H20FN3O3

>98% (HPLC)

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FC=1C=C2C(C(=NO2)C3CCN(CCN4C(=O)C=5C(C4=O)=CC=CC5)CC3)=CC1

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(-20℃)

With Ice Pack

≥ 2 years